Protein Details: Glutamate receptor ionotropic; kainate 1

Protein ID

ICDB_Pro_0414

Protein Name

Glutamate receptor ionotropic; kainate 1

Gene Name

Grik1; Glur5

Organism

Rattus norvegicus (Rat)

Length

949 amino acids

AlphaFoldDB

AF-P22756-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel; gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change; leading to the opening of the cation channel; and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state; characterized by the presence of bound agonist.

Sequence

MERSTVLIQPGLWTRDTSWTLLYFLCYILPQTSPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDSRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPPANKDAKPLLKEMKKSKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRKLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPCALGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEAYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFLYKSRKNNDVEQKGKSSRLRFYFRNKVRFHGSKKESLGVEKCLSFNAIMEELGISLKNQKKLKKKSRTKGKSSFTSILTCHQRRTQRKETVA

PDB Structures

1TXF 1VSO 1YCJ 2F34 2F35 2F36 2OJT 2PBW 2QS1 2QS2 2QS3 2QS4 2WKY 3C31 3C32 3C33 3C34 3C35 3C36 3GBA 3GBB 3S2V 4DLD 4E0X 4QF9 4YMB 5M2V 5MFQ 5MFV 5MFW 5NEB 5NF5 6FZ4 6SBT 7LVT

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 531; /ligand="L-glutamate"; BINDING 533; /ligand="L-glutamate"; BINDING 538; /ligand="L-glutamate"; BINDING 704; /ligand="L-glutamate"; BINDING 705; /ligand="L-glutamate"; BINDING 753; /ligand="L-glutamate"

Disease

Location

Expressed in the olfactory bulb (at protein level) (PubMed:10023812). Expressed in subsets of neurons throughout the developing and adult central and peripheral nervous systems. In the CNS principally in the medial amygdaloid nuclei; medial habenulae; pyriform and cingulate cortices; and Purkinje cell layer. In the CNS principally in the medial amygdaloid nuclei; medial habenulae; pyriform and cingulate cortices; and Purkinje cell layer. In the CNS principally in the medial amygdaloid nuclei; medial habenulae; pyriform and cingulate cortices; and Purkinje cell layer. Also highly expressed in embryonic and adult dorsal root ganglia (PubMed:1977421). Expressed at high levels in the trigeminal ganglion neurons (PubMed:9254673).

DOI ID

10.1002/j.1460-2075.1992.tb05211.x; 10.1016/0896-6273(90)90213-y; 10.1074/jbc.m608194200; 10.1016/0014-5793(92)80753-4; 10.1523/jneurosci.17-17-06611.1997; 10.1002/(sici)1096-9861(19990308)405:2<233::aid-cne7>3.0.co;2-a; 10.1523/jneurosci.21-13-04572.2001; 10.1016/s0896-6273(03)00369-6; 10.1016/j.neuroscience.2014.08.009; 10.1016/j.febslet.2005.01.012; 10.1016/j.neuron.2005.01.031; 10.1523/jneurosci.0123-06.2005

RefSeq

NP_001104584.1; NP_001104587.1; NP_058937.1